罗帅宇第一作者论文
不同类型排斥反应受者血常规及外周血淋巴细胞亚群特征性变化(全文共九页，每天发一页，请大家理性评论） 第二页
Characteristic changes in blood routine and peripheral
blood lymphocyte subpopulations in recipients of
different types of rejection
LUO Shuaiyu1, 2
, NIE Manhua1, 2
, SONG Lei1, 2
, XIE Yixin1, 2
, ZHONG Mingda1, 2
, TAN Shubo1, 2, 3
,
AN Rong1, 2
, LI Pan1, 2
, TAN Liang1, 2
, XIE Xubiao1, 2
(1. Department of Kidney Transplantation, Second Xiangya Hospital of Central South University,
Changsha 410011; 2. Clinical Research Center for Organ Transplantation in Hunan Province, Second Xiangya
Hospital, Central South University, Changsha 410011; 3. Department of Urology, Institute of Urology
Transplantation, Second Hospital, University of South China, Hengyang Hunan 421001, China)
ABSTRACT Objective: Rejection remains the most important factor limiting the survival of
transplanted kidneys. Although a pathological biopsy of the transplanted kidney is the gold
standard for diagnosing rejection, its limitations prevent it from being used as a routine
monitoring method. Recently, peripheral blood lymphocyte subpopulation testing has
become an important means of assessing the body’s immune system, however, its
application value and strategy in the field of kidney transplantation need further
exploration. Additionally, the development and utilization of routine test parameters are
also important methods for exploring diagnostic strategies and predictive models for kidney
transplant diseases. This study aims to explore the correlation between peripheral blood
lymphocyte subpopulations and T cell-mediated rejection (TCMR) and antibody-mediated
rejection (ABMR), as well as their diagnostic value, in conjunction with routine blood tests.
Methods: A total of 154 kidney transplant recipients, who met the inclusion and exclusion
criteria and were treated at the Hospital in 2021, were selected as the study subjects. They
were assigned into a stable group, a TCMR group, and an ABMR group, based on the
occurrence and type of rejection. The basic and clinical data of these recipients were
retrospectively analyzed and compared among the 3 groups. The transplant kidney
function, routine blood tests, and peripheral blood lymphocyte subpopulation data of the
TCMR group and the ABMR group before rejection treatment were compared with those of
the stable group.
Results: The stable, TCMR group, and ABMR group showed no statistically significant
differences in immunosuppressive maintenance regimens or sources of transplanted
kidneys (all P>0.05). However, the post-transplant duration was significantly longer in the
ABMR group compared with the stable group (P<0.001) and the TCMR group (P<0.05).
Regarding kidney function, serum creatinine levels in the ABMR group were higher than in
the stable group (P<0.01) and the TCMR group (P<0.005), with the TCMR group also
showing higher levels than the stable group (P<0.01). Both TCMR and ABMR groups had
significantly higher blood urea nitrogen levels than the stable group (P<0.01), with no
statistically significant difference between TCMR and ABMR groups (P>0.05). The
estimated glomerular filtration rate (eGFR) was lower in both TCMR and ABMR groups
compared with the stable group (both P<0.01). In routine blood tests, the ABMR group had